最高學歷：高雄醫學大學醫學博士
現任經歷：慈濟大學醫學科學研究所教授兼眼暨視覺科教授,
花蓮慈濟醫院眼科研究中心主任
研究領域： 1.神經保護 2.動物模式 3.再生醫學 4.神經眼科 5.轉譯醫學
電話：03-8561825 分機 12718, 12112
e-mail： rktsai@mail.tcu.edu.tw
研究計畫：
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序號 |
獎助單位 |
計劃編號 |
研究計劃名稱 |
執行期間(起) |
執行期間(迄) |
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1 |
Buddhist Tzu Chi General Hospital | TCRD 96-16 | Molecular study of TNFa induced human retinal pigment epithelial cell migration |
2007 |
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2 |
National Science Council | Effect of optic nerve regeneration by G- CSF (granulocyte-colony stimulation factor) administration in animal model of chronic elevation of intraocular pressure |
2007 |
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3 |
Buddhist Tzu Chi General Hospital | TCRD 98-4 | Neuroprotective effect of Memantine and Etanercept for Retinal Ganglion Cells in animal model of optic nerve crush |
2008 |
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4 |
Buddhist Tzu Chi General Hospital | TCRD 99-03 | Mechanisms of the Recombinant Human Granulocyte Colony-stimulating factor (G-CSF) Inducing Anti-apoptotic Effects on Retinal Ganglion Cells after Optic Nerve Crush in Rats |
2009 |
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5 |
National Science Council | Comparative study among neuroprotective drugs on optic nerve and retinal ganglion cells in animal model of optic nerve crush |
2008 |
2010 |
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6 |
Buddhist Tzu Chi General Hospital | TCRD 99-03 | Neuroprotective Effects of Human Umbilical Mesenchymal Stem Cells and Adipose-derived Stromal Cells after Optic Nerve Crush in Rats |
2010 |
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7 |
Buddhist Tzu Chi General Hospital | TCRD 100-31 | A rodent model of non-arteritic anterior ischemic optic neuropathy |
2011 |
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8 |
National Science Council | 100-2314-B-303-005 | Therapeutic strategies for non-arteritic anterior ischemic optic neuropathy (NAION) in a rat model |
2011 |
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9 |
Buddhist Tzu Chi General Hospital | TCRD 101-14 | Neuroprotective effects of granulocyte colony-stimulating factor (G-CSF) and etanercept (Enbrel) in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION) |
2012 |
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10 |
Buddhist Tzu Chi General Hospital | TCRD-I- 101-01 | A trial for neuroprotective effect of granulocyte colony-stimulating factor (G-CSF) in traumatic optic neuropathy |
2012 |
2013 |
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11 |
National Science Council | 102-2314-B-303-008 | Therapeutic effects and molecular mechanism of steroid administration in a rat model of anterior ischemic optic neuropathy (rAION) |
2013 |
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12 |
Buddhist Tzu Chi General Hospital | TCRD 103-20 | Neuroprotective effects of P-selectin in an optic nerve crush model |
2014 |
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13 |
Ministry of Science and Technology | 大白鼠前缺血性視神經病變模式中使用 G-CSF及合併療法的效用及分子機轉探討 |
2014.8 |
2017.7 |
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14 |
Tzu Chi Medical Center | The role of P62 expression in a rat model of optic nerve crush. |
2015.1 |
2015.12 |
著作：
1.Lin SF, Lin PK, Chang FL, Tsai RK*. Transient hyperopia after intensive treatment of hyperglycemia in newly diagnosed diabetes. Ophthalmologica 2009 Nov;223:68–71 (SCI)
2.Chang YC and Tsai RK*. Coexistence of optic nerve head drusen and combined hamartoma of the retina and retinal pigment epithelium in a taiwanese male. A case report. Kaohsiung J Med Sci 2009 Jan; 25(1): 40-43. (SCI)
3.Huang ZL, Lin KH, Lee YC, Sheu MM, Tsai RK*. Acute Visual Loss after Intravitreal Injection of Bevacizumab (Avastin) Associated with Ocular Ischemic Syndrome. Ophthalmologica 2009 Aug 26; 224(2):86-89. (SCI)
4.Hsu SY, Sheu MM, Hsu AH, Wu KY, Yeh JI, Tien JN and Tsai RK*. Comparisons of intraocular pressure measurements: Goldmann applanation tonometry, noncontact tonometry, Tono-Pen tonometry, and dynamic contour tonometry. Eye 2009 Jul; 23(7):1582-8. (SCI)
5.Tsai RK. Trends of therapeutic strategy for non-arteritic anterior ischemic optic neuropathy. Taiwan J Ophthalmol2009 Dec; 48(4):492-493.
6.Tsai RK. Neuroprotective treatment for neurodegeneration of optic nerve diseases. Taiwan J Ophthalmol 2009 Dec; 48(4):504-505.
7.Lin SF and Tsai RK. Reply. Ophthalmologica 2009 Aug 26; 224(1):64. (SCI)
8.Huang ZL, Lin KH, Sheu MM, Tsai RK*. Optical coherence tomography of a coexisting optic nerve cyst and optic disc pit: a case report. Kaohsiung J Med Sci2010, 26(5):262-266. (SCI)
9.Lin YC, He MS and Tsai RK*. Cytomegalovirus retinitis in a patient of idiopathic thrombocytopenic purpura with oral Prednisolone treatment: a case report. Taiwan J Ophthalmol 2010 Mar; 49(1):42-48.
10.Tsai RK*, Chang CH, Sheu MM, Huang ZL. Anti-apoptotic effects of human granulocyte colony-stimulating factor (G-CSF) on retinal ganglion cells after optic nerve crush are PI3K/AKT-dependent. Exp. Eye. Res. 2010 May; 90(5):537-45. (SCI)
11.Huang ZL, Hsu SY, Tsai RK, Sheu MM*. Etiology of ocular diseases in elderly Amis aborigines in Eastern Taiwan (The Amis Eye Study). Jpn. J Ophthalmol. 2010 Jul; 54(4):266-71. (SCI)
12.Huang ZL, Kao RH, Lin YC, Tsai RK*. Isolated papaneoplastic optic neuropathy associated with acute lymphoblastic leukemia and collapsin response-mediating protein (CRMP-5) autoantibody. Neuro-ophthmology Japan 2010; 27(3): 337-343.
13.Hsu CH, He MS, Huang ZL, Tsai RK*. Choroidal metastasis as the main presentation of lung adenocarcinoma: a case report. Taiwan J Ophthalmol 2010 Sep; 49(3):371-376.
14.Huang ZL, Chang CH, Lin KH, Sheu MM and Tsai RK*. Lack of protective effect of local administration of triamcinolone or systemic treatment with methylprednisolone against damages caused by optic nerve crush in rats. Exp Eye Res 2011 Feb 92(2)112-119. (SCI)
15.Chen N, Tsai RK and Sheu MM*. Panuveitis as the initial manifestation of syphilis with concurrent HIV infection. Acta Soc Ophthalmol Sinicae 2011 Apr 50(1)134-140.
16.Tsai RK, He MS, Chen ZY, Wu WC and Wu WS*. PKCδ-dependent signaling mediates ethambutol-induced toxic effects on human retinal pigment cells. Mol Vis 2011 June 9(17)1564-1576.(SCI)
17.Huang TL, Huang YC, Lin KH, Sheu MM and Tsai RK*. Unilateral ocular sarcoidosis associated with interferon therapy. Tzu Chi Med J 2011: 23; 96-99.
18.Hsu CY, Lai YU, Hsu SY, Lin YC, Tsai RK*. Optical coherence tomography (OCT) findings in patients with optic tract syndrome. Taiwan Journal of Ophthalmology 1 (2011) 16-20.
19.Chen N, Huang TL and Tsai RK*. Spectral Domain Optical Coherence Tomography Findings of Juxtapapillary Choroidal Nevus. Neuro-Ophthalmology 2012: 36(1); 20-22. (SCI) case
20.Lin HZ, Pang CY, Chen SP and Tsai RK*. Vision Improvement in A Taiwanese (Han Chinese) Family with Leber’s Hereditary Optic Neuropathy. Kaohsiung J Med Sci, 2012 Dec: 28(12); 679-682. (SCI)case
21.Tsai RK. This Issue at a Glance. Taiwan Journal of Ophthalmology 2 (2012) 39-40.
22.Lee YC, Chang FL, Tsai RK*. Intravenous pulse steroid therapy in euthyroid optic neuropathy. A case report. Neuro-Ophthalmology 2012 Aug ;36(4): 143-145 .(SCI) 0.256/55/58=95%
23.Hsu SY*, Ko ML, Linn G, Chang MS, Sheu MM, Tsai RK. Effects of age and disc area on optical coherence tomography measurements and analysis of correlations between optic nerve head and retinal nerve fibre layer. Clin Exp Optom. 2012 Jul; 95(4):427-31.(SCI) 1.407/31/58=53%
24.Chen N, Huang TL, Tsai RK, Sheu MM*. Prevalence and causes of visual impairment in elderly Amis aborigines in eastern Taiwan (the Amis Eye Study). Jpn J Ophthalmol. 2012 Sep; 56:624–630 (SCI) 0.924/44/58=75.8%
25.Chen YJ, Tsai RK, Wu WC, He MS, Kao YH, Wu WS. Enhanced PKC delta and ERK signaling mediate cell migration of retinal pigment epithelial cells synergistically induced by HGF and EGF. PLoS One. 2012 Sep; 7(9):e44937. doi: 10.1371/journal.pone.0044937. (SCI) 4.092/12/85=14.1%
26.Fang TC, Pang CY, Chiu SC, Ding DC, Tsai RK. Renoprotective effect of human umbilical cord-derived mesenchymal stem cells in immunodeficient mice suffering from acute kidney injury. PLoS One. 2012 Sep; 7(9):e46504. doi: 10.1371/journal.pone.0046504. (SCI)
27.Yang YY, Chen N, Wu MS, Tsai RK*. Traumatic superior orbital fissure syndrome. A case report. Acta Soc Ophthalmol Sinicae 2012 Oct 51(2)198-202.
28.He MS, Sheu MM, Huang ZL, Tsai CH, Tsai RK*. Sudden bilateral visual loss and brain infarction following cosmetic hyaluronic acid injection. JAMA Ophthalmol 2013 Sep 131(9):1234-5. (SCI)
29.Huang TL, Lin KH, Tsai RK*. Treatment strategy of non-arteritic anterior ischemic optic neuropathy. Tzu Chi Med J 2013 Sep 25(3):135-138.
30.Lin JL, He MS, Tsai RK*. Ocular manifestations as the initial presentations of Wilson disease. Taiwan Journal of Ophthalmology 2013 3:173-175.
31.Huang SP, Tsai RK*. The mechanisms of retinal ganglion cell death in optic neuropathies. Neuro-ophthalmology Japan 2013 Jue 30(2):217-224.
32.Chen N, Huang TL, Hsu YH, Lin HZ, Tsai RK*. Orbital manifestations of IgG4-related disease in bilateral lacrimal glands, optic nerves, trigeminal nerves and maxillary sinuses. Neuro-Ophthalmology 2014 38(1):24-28. (SCI)
33.Huang SP, Tsai RK*. Regenerative medicine in optic neuropathy. Neuro-ophthalmology Japan 2013 Sep 30(3):315-319.
34.Chang CH, Huang TL, Huang SP, Tsai RK*. Neuroprotective effects of recombinant human granulocyte colony-stimulating factor (G-CSF) in a rat model of anterior ischemic optic neuropathy (rAION). Exp Eye Res 2014 118:109-116 (SCI)
35.Huang TL, Huang SP, Lin KH, Tsai RK*. Management of non-arteritic anterior ischemic optic neuropathy. Neuro-ophthalmology Japan 2013 Dec 30(4):425-429.
36.Huang TL, Huang SP, Chang CH, Lin KH, Sheu MM, Tsai RK*. Factors influencing the retrograde labeling of retinal ganglion cells with Fluoro-gold in an animal optic nerve crush model. Ophthalmic Res 2014;51:173-178 (DOI: 10.1159/000357736) (SCI)
37.Lai YH, Huang SP, Chen SP, Hu PS, Lin SF, Sheu MM, Wang HZ, Tsai RK*. A Novel Gene Mutation in a Family with X-Linked Retinoschisis. Journal of the Formosan Medical Association 2014 Feb 13. pii: S0929-6646(14)00006-0. doi: 10.1016/j.jfma.2014.01.001. [Epub ahead of print] (SCI)
38.Huang TL, Huang SP, Lin KH, Chang CH, Sheu MM, Tsai RK*. Protective effects of cerebrolysin in a rat model of optic nerve crush. Kaohsiung J Med Sci, 2014 Jul, 30(7):331-336.(SCI)
39.Cheng HC, Tsai RK, Woung LC, Yen MY, Wang AG*. Roceedings of the Neuro-ophthalmology Symposium in the 54th Annual Meeting of the Ophthalmological Society of Taiwan, November 30, 2013, Taipei, Taiwan. Neuro-Ophthalmology 2014 38(3):167-169. (SCI)
40.Lee YC, Huang TL, Sheu MM, Liu PK, Tsai RK*. Intravitreal injection of triamcinolone acetonide in nonarteritic anterior ischemic optic neuropathy. Taiwan Journal of Ophthalmology 2014 4(2):86-89.
41.Lee YC, Huang TL, Tsai RK*. Orbital sarcoidosis – a case report. Tzu Chi Med J 2014.4.21 accepted
42.Chang CH, Tsai RK, Tsai MH, Lin YH, Hirobe T. The Roles of Frizzled-3 and Wnt3a on Melanocyte Development: in Vitro Studies on Neural Crest Cells and Melanocyte Precursor Cell Lines. Journal of Dermatological Science 2014 75:100-108. (SCI)
43.Lin HZ, Huang SP, Tsai RK*. Treatment of Leber’s hereditary optic neuropathy-an update. Neuro-ophthalmology Japan 2014 March 31(1):89-91.
44.Liu YC, Hsu YH, Shu MM, Tsai RK*. Basaloid squamous cell carcinoma of the conjunctiva. Ophthal Plast Resconstr Surg 2014 DOI: 10.1097/IOP.0000000000000056 case (SCI)
45.Huang SP, Tsai RK*. Effcacy of granulocyte-colony stimulating factor treatment in a rat model of anterior ischemic optic neuropathy. Neural Regen Res. 2014; 9(16):1502-1505.
46.Huang TL, Chen N, Lin KH, Tsai RK*.Current treatment of traumatic optic neuropathy. Neuro-ophthalmology Japan 2014 June 31(2):259-263.
47.Chen Nancy, Huang TL, Tsai RK*. Neuroprotection in Glaucoma: the odyssey against degeneration. Neuro-ophthalmology Japan 2014 Sep 31(3):377-381.
48.Tsao WS, He MS, Tsai RK*. Varicella zoster virus-associated neuroretinitis. A case report. Taiwan Journal of Ophthalmology 2014
49.Huang TL, Huang SP, Chang CH, Lin KH, Chang SW, Tsai RK*. Protective effects of systemic treatment with methylprednisolone in a rodent model of non-arteritic anterior ischemic optic neuropathy (rAION). Exp Eye Res 2014 Dec131: 69-76 (DOI: 10.1016/j.exer.2014.12.014) (SCI)
50.Huang TL, Chang CH, Chang SW, Lin KH, Tsai RK*. Efficacy of intravitreal injections of anti-vascular endothelial growth factor agents in a rat model of anterior ischemic optic neuropathy. IOVS IOVS-14-15999; published ahead of print March 10, 2015, doi:10.1167/iovs.14-15999 (SCI)
51.The gene mutation in a Taiwanese family with X-linked retinoschisis. Kaohsiung J Med Sci, 2015 Jue. Accepted (SCI)