最高學歷： 美國內華達州大生化學博士
現任經歷： 慈濟大學醫學科學研究所教授
研究領域： 1.血管生物學 2.心血管疾病機制 3.機械力對細胞的影響 4.氧化逆境及一氧化氮
電話：03-8565301 分機 2016
電子信箱： lingwang15@mail.tcu.edu.tw
近五年指導研究生名單：
1. 曾曉慧，中央研究院國際研究生學程(已畢業)
2. 陳長庭，台灣大學化工所(已畢業)
3. 吳立竑，慈濟大學醫學科學研究所
研究計畫：
|
序號 |
獎助單位 |
計劃編號 |
研究計劃名稱 |
執行期間（起） |
執行期間（迄） |
|
1 |
行政院國家科學委員會 | NSC 99-2320-B-320-018-MY3 | 流體力對血管內皮細胞的保護機制(1/3) |
2010/8/1 |
2011/7/31 |
|
2 |
行政院國家科學委員會 | NSC 99-2314-B-320-007-MY3 | 研究缺氧及再灌氧傷害對於血管內皮細胞微型核糖核酸(MicroRNA)調控作用之分子機轉(1/3) |
2011/6/1 |
2011/7/31 |
|
3 |
行政院國家科學委員會 | NSC 99-2314-B-320-007-MY3 | 研究缺氧及再灌氧傷害對於血管內皮細胞微型核糖核酸(MicroRNA)調控作用之分子機轉(2/3) |
2011/8/1 |
2012/7/31 |
|
4 |
行政院國家科學委員會 | NSC 99-2320-B-320-018-MY3 | 流體力對血管內皮細胞的保護機制(2/3) |
2011/8/1 |
2012/7/31 |
|
5 |
行政院衛生署中醫藥委員會 | CCMP 101-RD-031 | 雷公藤對Cisplatin抑制腫瘤生長及血管新生之影響(2-1) |
2012/6/1 |
2012/12/15 |
|
6 |
行政院國家科學委員會 | NSC 99-2320-B-320-018-MY3 | 流體力對血管內皮細胞的保護機制(3/3) |
2012/8/1 |
2013/7/31 |
|
7 |
行政院國家科學委員會 | NSC 99-2314-B-320 -007 -MY3 | 研究缺氧及再灌氧傷害對於血管內皮細胞微型核糖核酸（MicroRNA）調控作用之分子機轉(3/3) |
2012/8/1 |
2013/7/31 |
|
8 |
行政院衛生署中醫藥委員會 | CCMP102-RD-112 | 雷公藤對Cisplatin抑制腫瘤生長及血管新生知交互作用(2-2) |
2013/1/22 |
2013/12/15 |
|
9 |
行政院國家科學委員會 | NSC 102-2320-B-320-010 | 內皮細胞內SIRT3在維持粒線體正常運作的功能角色 |
2013/8/1 |
2014/7/31 |
|
10 |
科技部 | THE PROTECTIVE ROLE OF SIRTUIN 3 (SIRT 3) IN ENDOTHELIAL CELLS: MITOCHONDRIAL HOMEOSTAIS ASPECT |
2014/8/1 |
2015/7/31 |
著作：
1. Chung-Yu Hsieh, Huai-Yu Hsiao, Wan-Yi Wu, Ching-Ann Liu, Yu-Chih Tsai, Yuen-Jen Chao, Wang D. L. and Hsyue-Jen Hsieh. Regulation of shear-induced nuclear translocation of the Nrf2 transcription factor in endothelial cells J. Biomedical Sciences 16:22 (2009)
2. Chen S-C, Wu S-E, Wang D. L.,Chen Shih-chung The Inhibition in Tumor Necrosis Factor-a-induced Attenuation in Endothelial Thrombomodulin Expression by Carvedilol Is Mediated by Nuclear Factor-kB and Reactive Oxygen Species J. of Thromb. and Thrombolys. (in press). 2009
3. Huang B., Chen S-C and Wang DL. Shear Flow Increases Proteins’ S-nitrosylation in Endothelial Cells. Cardiovascular Res.83:536-546, (2009).
4. Huang B, Liao C-L, and Wang DL“S-nitrosoproteome in Endothelial Cells Revealed by a Modified Biotin Switch Approach Coupled with Western Blot based Two-dimensional Gel Electrophoresis” J. Proteome Res. 8(10):4835-4843, 2009
5. Chen S-C, Wu S-E, Wang D. L. The Inhibition in Tumor Necrosis Factor-a-induced Attenuation in Endothelial Thrombomodulin Expression by Carvedilol Is Mediated by Nuclear Factor-kB and Reactive Oxygen Species J. of Thromb. and Thrombolys. 29:52-59 (2010)
6. Steward R.L. Jr., Chen C-M, Wang DL and LeDuc P. R. “Probing Cell Structure Responses through a Shear and Stretching Mechanical Stimulation Technique” Cell Biochemistry and Biophysics 56:115-124 (2010)
7. Chen S-C, Lin Y-L, Lin S-J, Wang DL. and Cheng J-J “Salvianolic acid B suppresses IFN-γ-Induced JAK/STAT1 activation in Endothelial Cells” Throbmosis Res. (in press) (2011).
8. Huang B, Li F-A, Wu C-H, Wang D.L. “The role of nitric oxide on rosuvastatin-mediated S-nitrosylation and translational proteome in endothelial cells” Proteome Science 10:43-47, 2012.
9. Chen Z. Wang W-C, Sun W, Wang Y-T, Lai T-C, Fang T, Cui X, Padmanabhan C, Sun R, Chen S-C, Wang D.L. Jin H, Huang H-D, Hsiao M, Shyy JY-J, “Angioogenesis enhancement by miRNA targeting of Ago1: A hypoxia-induced transcriptional de-supression mechanism” J. Clin. Invest. 123(3):1057-1067, 2013.
10. Huang B, Wu CH, Li FA, Liang SS, Shieh YH, Wang DL. “Rosuvastatin-regulated post-translational phosproteome in human umbilical vein endothelial cells. Kaoshiung J. Medical Sciences. 29(7 ):1-6, 2013.
11. Tseng A H-H, S-S Shieh, Wang D.L. “SIRT3 deacetylates FOXO3 to promote mitochondrial homeostasis” Free Radical Biology and Medicine 63:222-234,( 2013).
12. Tseng A H-H, Shieh S-S, Wang D.L. “SIRT3 cross-talks with FOXO3 acetylation-phosphorylation-ubiquitination to mediate hypoxic adaptation” Antioxidant Redox. Signaling (submitted), 2013.
13. Hsieh H-J, Liu C-A, Wang D.L., “Shear-induced endothelial mechanotransduction: role of ROS and NO” (review article). J. Biomedical Sciences (2013). (under minor revision).
14.A.H-H Tseng, L-H Wu, S-S Shieh, D. L. Wang*. SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell response to hypoxia. Biochemical Journal,464:157-168. 2014.
15.Hsieh H-J, Liu C-A, Huang B, Tseng AHH, Wang D.L.*. Shear-induced endothelial mechanotransduction: the interplay between reactive oxygen species (ROS) and nitric oxide (NO) and the pathophysiological implications” (highly access). Journal of Biomedical Science,21:3-27. 2014.