最高學歷： 國防醫學院生命科學博士
現任經歷： 慈濟大學醫學科學研究所教授
研究領域：1. 癌症生物學, 2. 血小板凝集反應及血管功能研究, 3. 發炎性疾病及治療, 4. 中草藥及天然物療效研究
電話：03-8561825 分機 15620
電子信箱： tcchou48@mail.tcu.edu.tw
近五年指導研究生名單：
1.蔡鎮良，國防醫學院醫學科學研究所
2.陳孟專，國防醫學院醫學科學研究所
3.余文鈞，國防醫學院生命科學研究所
4.林宥潔，國防醫學院生命科學研究所
5.施靖瑜，國防醫學院生命科學研究所
6.呂聖華，國防醫學院生命科學研究所
研究計畫：
|
序號 |
獎助單位 |
研究計劃名稱 |
執行期間（起） |
執行期間（迄） |
|
1 |
國防部 | 研究熱中暑誘發凝血功能異常之機轉及可能的治療藥物 | 99/1/1 | 99/12/31 |
|
2 |
奇美醫院 | 評估具潛力藥物對內毒素所誘發的急性肺損傷的療效及可能機轉 | 99/1/1 | 99/12/31 |
|
3 |
行政院國家科學委員會 | 探討黃芩素對內毒素所誘發之急性肺損傷的療效及機轉 | 97/8/1 | 100/7/31 |
|
4 |
生物技術開發中心 | 牛樟芝分離物在LLC肺癌轉移動物藥理試驗 | 101/1/1 | 101/12/31 |
|
5 |
生物技術開發中心 | 厚朴分離物治療牙周病抑菌與動物藥理實驗(1-2) | 102/1/1 | 103/12/31 |
|
6 |
科技部 | 厚朴酚之抗腫瘤轉移及改善化療藥物所誘發之副作用研究 | 103/08/01 | 104/07/31 |
|
7 |
科技部 | 具調節血糖及改善糖尿病腎病變功效之牛樟芝保健食品開發 | 103/12/01 | 105/11/30 |
著作：
*Correspondence author
1. Chou TC, Yen MH, Li CY., Ding YA: Alterations of nitric oxide synthase expression with aging and hypertension in rats. Hypertension 31:643-648, 1998. (SCI)
2. Chen A, Sheu LF, Ho YS, Lin YF, Chou WY, Chou TC, Lee WH: Experimental focal segmental glomeruloslerosis in mice. Nephron 78:440-452, 1998. (SCI)
3. Li CY, Chou TC, Wu CC, Wong CS, Ho ST, Ding YA: Dantrolene inhibits nitric oxide synthase in rat alveolar macrophages treated with lipopolysaccharide and interferon-γ. Can J Anaesth 45:246-252, 1998. (SCI)
4. Chou TC *, Li CY, Wu CC, Yen MH, Ding YA: The inhibition by dantrolene of L-arginine transport and nitric oxide synthase in rat alveolar macrophages. Anesth Analg 86: 1065-1069, 1998. (SCI)
5. Hu MK, Yang FC, Chou TC, Yen MH: Synthesis and evaluation of backbone/amide-modified analogs of leualacin. Bioorg Med Chem Lett 9: 563-568, 1999. (SCI)
6. Chou TC *, Li CY, Yen MH, Ding YA: Antiplatelet effect of amlodipine: A possible mechanism through nitric oxide mediated process. Biochem Pharmacol 58;10:1657-1663, 1999. (SCI)
7. Chou TC *, Li CY: Inhibitory mechanisms of dantrolene on platelet aggregation. Thromb Res 96:299-307, 1999. (SCI)
8. Wu TM, Chou TC, Ding YA, Li ML: Stimulation of TNF-α and IL-β and nitrite release from mouse cultured spleen cells and lavaged peritoneal cells by mastoparan M. Immunol Cell Biol 77:476-82, 1999. (SCI)
9. Wu TM, Li ML, Chou TC*: Inhibitory effect of hexapeptide (RGRHGD) on platelet aggregation. Thromb Res 97: 191-199, 2000. (SCI)
10. Chou TC*, Li CY, Lee AR, Wu TM: Mechanism of inhibition of platelet aggregation by HCL-31D. Eur J Pharmacol 387: 125-131, 2000. (SCI)
11. Wu CC, Liao MH, Chen SJ, Chou TC, Chen A, Yen MH. Tertbutaline prevents circulatory failure and mitigates mortality in rodents with endotoxemia. Shock 14:60-67, 2000. (SCI)
12. Chou TC*: Nitric oxide and hypertension. Acta Cardiol Sin 16:131-142, 2000.
13. Fu E, Chou TC, Liu D, Chiu SC: Ameliorated effect of L-arginine supplementation on gingival morphology in cyclosporine-treated rats. J Periodontol 8: 1737-1742, 2000. (SCI)
14. Chou TC*, Li CY, Wu TM, Tang ST, Lee AR, Ding YA: Beneficial effect of HCL-31D in murine models of endotoxaemia. Naunyn-Schmiedeberg’s Arch Pharmacol 364: 213-219, 2001. (SCI)
15. Hsu MM, Chou YY, Chang YC, Chou TC, Wong CS: An analysis of excitatory amino acids, nitric oxide and prostaglandin E2 in the cerebrospinal fluid of pregnant women: the effect on labor pain. Anesth Analg 93, 1293-1296, 2001. (SCI)
16. Chou TC*, Yang SP, Pei D: Amlodipine inhibits pro-inflammatory cytokines and free radical production and inducible nitric oxide synthase expression in lipopolysaccharide/interferon-g-stimulated cultured vascular smooth muscle cells. Jpn J Pharmacol 89, 157-163, 2002. (SCI)
17. Hsu WC, Tao TM, Chou TC, Ding YA, Liu KC: Condensed naphtho[1,8-de][1,3]thiazines 1. Synthesis of naphtho[1,8-de][1,2,4] triazolo[3,4-b][1,3]thiazine derivatives and their inhibitory activity on human platelet aggregation. Chin Pharm J 54, 331-352, 2002.
18. Li CY, Chou TC, Lee CH, Tsai CS, Loh SH, Wong CS: Adrenaline Inhibits Lipopolysaccharide-Induced Macrophage Inflammatory Protein-1a in Human Monocytes: the Role of b-Adrenergic Receptors. Anesth Analg 96, 518-523, 2003. (SCI)
19. Lin YF, Wang JY, Chou TC, Lin SH. Vasoactive mediators and renal haemodynamic in exertional heat stroke complicated by acute renal failure. Q J Med 96, 1-9, 2003. (SCI)
20. Chou TC*, Fu E, Wu CJ, Yeh JH: Chitosan enhances platelet adhesion and aggregation. Biochem Biophy Res Comm, 302, 480-483, 2003. (SCI)
21. Chou TC*: Anti-inflammatory and analgesic effects for paeonol in carrageenan-evoked thermal hyperalgesia . Br J Pharmacol 139, 1146-1152, 2003. (SCI)
22. Chou TC*, Fu E¸ Shen EC: Chitosan inhibits prostaglandin E2 formation and cyclooxygenase-2 induction in lipopolysaccharide-treated RAW 264.7 macrophages. Biochem Biophy Res Comm 308, 403-407, 2003. (SCI)
23. Chou TC*, Chang LP, Li CY, Wong CS, Yang SP: Anti-inflammatory and analgesic effect of baicalin. Anesth Analg 97,1724-1729, 2003. (SCI)
24. Huang WH, Lee AR, Chien PY, Chou TC. Synthesis of baicalein derivatives as potential anti-aggregatory and anti-inflammatory agents. J Pharm Pharmacol 57:219-225, 2005. (SCI)
25. Chang H, Kuo FC, Lai YS, Chou TC*. Inhibition of inflammatory responses by FC-77, a perfluorochemical, in lipopolysaccharide-treated RAW 264.7 macrophages. Intensive Care Med 31:977-984, 2005. (SCI)
26. Gau CH, Chou TC, Chiu SC, Shen EC, Nieh S, Chiang CY, Fu E. Effect of cyclosporine-a on the expression of inducible nitric oxide synthase in gingiva of rats. J Periodontol 76:2260-2266, 2005. (SCI)
27. ChiuHF, YangSP, KuoYL, LaiYS, Chou TC*. Mechanisms involved in the antiplatelet effect of c-phycocyanin. Br J Nutr 95:434-439, 2006. (SCI)
28. Cherng SC, Huang WH, Shiau CY, Lee AR, Chou TC*. Mechanisms of antiplatelet activity of PC-09, a newly synthesized pyridazinone derivative. Eur J Pharmacol, 532:32-37, 2006. (SCI)
29. Shen EC, Chou TC, Gau CH, Tu HP, Chen YT, Fu E. Releasing growth factors from activated human platelets after chitosan stimulation: a possible bio-material for platelet-rich plasma preparation. Clin Oral Implant Res, 17:572-578, 2006. (SCI)
30. CherngSC, ChengSN, Tarn A, Chou TC*. Anti-inflammatory activity of c-phycocyanin in lipopolysaccharide-stimulated RAW 264.7 macrophages. Life Sci 81:1431-1435, 2007. (SCI)
31. Chou TC*, Lin YF, WuWC, Chu KM. Enhanced nitric oxide and cyclic GMP formation plays a role in the antiplatelet activity of simvastatin. Br J Pharmacol 153:1281-1287, 2008. (SCI)
32. Shih CM, ChengSN, Wong CS, KuoYL, Chou TC*. Anti-inflammatory and analgesic activity of c-phycocyanin. Anesth Analg 108:1303-1310, 2009. (SCI)
33. ChangLP, LaiYS, Wu CJ, Chou TC*. Liquid perfluorochemical inhibits inducible nitric oxide synthase expression and nitric oxide formation in lipopolysaccharide-treated RAW 264.7 macrophages. J Pharmacol Sci 111:147-154, 2009. (SCI)
34. Yeh JH, Chiu HF, Wang JS, Lee JK, Chou TC*. Protective effect of baicalein extracted from Scutellaria baicalensis against lipopolysaccharide-induced glomerulonephritis in mice. Int J Pharmacol 6:81-88, 2010. (SCI)
35. Lai Y-S, Shih CY, Huang YF, Chou TC*. Antiplatelet activity of alpha-lipoic acid. J Agric Food Chem 58:8596-8603, 2010. (SCI)
36. ChouTC*, ShihCY, Chen YT. The inhibitory effect of alpha-lipoic acid on platelet aggregation is mediated by PPARs. J Agric Food Chem 59:3050-3059, 2011. (SCI)
37. Leung PO, Wang SH, Lu SH, Chou WH, Shiau CY, Chou TC*. Simvastatin inhibits pro-inflammatory mediators through induction of heme oxygenase-1 expression in lipopolysaccharide-stimulated RAW264.7 macrophages. Toxicol Lett 207:159-166, 2011. (SCI)
38. Shih CY, Chou TC*. The antiplatelet activity of magnolol is mediated by PPAR-b/g. Biochem Pharmacol 84:793-803, 2012. (SCI)
39. Bai MY*, Chou TC*, TsaiJC, Yang HC. Active ingredient-containing chitosan/polycaprolactone nonwoven mats: Characterizations and their functional assays. Mater Sci Eng C 33:224-233, 2013. (SCI)
40. LuSH, HuangRY, Chou TC*. Magnolol ameliorates ligature-induced periodontitis in rats and osteoclastogenesis: in vivo and in vitro study. Evid Based Complement Altern Med 2013: Article ID 634095, 2013. (SCI)
41. Lin YC; Lai YS; Chou TC*. The protective effect of alpha-lipoic acid in lipopolysaccharide-induced acute lung injury is mediated by heme oxygenase-1. Evid Based Complement Altern Med 2013: Article ID 590363, 2013. (SCI)
42. LeungPO, Lee HH, KungYC, TsaiMF, Chou TC*. Therapeutic effect of c-phycocyanin extracted from blue green algae in a rat model of acute lung injury induced by lipopolysaccharide. Evid Based Complement Altern Med 2013: Article ID 916590, 2013. (SCI)
43. ChenMC, LeeCF, HuangWH, Chou TC*. Magnolol suppresses hypoxia-induced angiogenesis via inhibition of HIF-1a/VEGF signaling pathway in human bladder cancer cells. Biochem Pharmacol 85:1278-1287, 2013. (SCI)
44. Huang SL, Chou TC, Lin TH, Tsai MS, Wang SH. Gcse, a novel germ-cell-specific gene, is differentially expressed during meiosis and gametogenesis. Reprod Sci 20: 1193-1206, 2013. (SCI)
45. ShihCY, LinMH, Fan HC, Chen FC, Chou TC*. Mechanisms of antiplatelet activity of nifedipine: role of peroxisome proliferator-activated receptor-β-γ-dependent processes. J Hypertens 32:181-192, 2014. (SCI)
46. ShihCY, LinIH, DingJC, ChenFC, Chou TC*. Antiplatelet activity of nifedipine is mediated by inhibition of NF-κB activation caused by enhancement of PPAR-β/-γ activity. Br J Pharmacol 171:1490-1500, 2014. (SCI)
47. TsaiCL, LinYC, WangHM, Chou TC*. Baicalein, an active component of Scutellaria baicalensis, protects against lipopolysaccharide-induced acute lung injury in rats. J Ethnopharmacol 153:197-206, 2014. (SCI)
48. BaiMY*, Chou TC*, TsaiJC, YuWC. The effect of active ingredient-containing chitosan/polycaprolactone nonwoven mat on wound healing: in vitro and in vivo studies. J Biomed Mater Res: Part A 102A:2324-2333, 2014. (SCI)
49. Chou TC*. New mechanisms of antiplatelet activity of nifedipine, an L-type calcium channel blocker. BioMedicine 4:17-24, 2014.
50. Lu SH, Chen TH, Chou TC*. Magnolol inhibits RANKL-induced osteoclast differentiation of RAW 264.7 macrophages through heme oxygenase-1-dependent inhibition of NFATc1 expression. J Nat Prod 78:61-68, 2015. (SCI)
51. Low P, Clark AM, Chou TC, Chang TC, Reynolds M, Ralph SJ. Immunomodulatory activity of Melaleuca alternifolia concentrate (MAC): Inhibition of LPS-induced NF-κB activation and cytokine production in myeloid cell lines. Int Immunopharmacol. 26:257-264, 2015. (SCI)
52. Chen TH, Shih CY, HsuWL, Chou TC*. Mechanisms of nifedipine-downregulated CD40L/sCD40L signaling in collagen stimulated human platelets. Plos One 10:e0127054, 2015 (SCI)
53. Lin MH, Chen MC, ChenTH, Chang HY, Chou TC*. Magnolol ameliorates lipopolysaccharide-induced acute lung injury in rats through PPAR-g-dependent inhibition of NF-kB activation. Int Immunopharmacol 28:270-278, 2015. (SCI)
54. Chen MC, Hsu WL, Hwang PA, Chou TC*. Low molecular weight fucoidan inhibits tumor angiogenesis through downregulation of HIF-1a/VEGF signaling under hypoxia. Marine Drugs. 13:4436-4451, 2015. (SCI)
55. Lu SH, Hsu WL, Chen TH, Chou TC*. Activation of Nrf2/HO-1 signaling pathway involves the anti-inflammatory activity of magnolol in Porphyromonas gingivalis lipopolysaccharide-stimulated mouse RAW 264.7 macrophages. Int Immunopharmacol 29:770-778, 2015. (SCI)
56.Chen MC, Chen YL, Lee CF, Huang CH, Chou TC*. Supplementation of magnolol attenuates skeletal muscle atrophy in bladder cancer-bearing mice undergoing chemotherapy via suppression of FoxO3 activation and induction of IGF-1. Plos One 10: e0143594, 2015. (SCI)