最高學歷： 台灣陽明大學生物化學研究所
現任經歷： 慈濟大學醫學科學研究所兼任副教授 , 慈濟醫學中心研究部副主任
研究領域：1.轉譯醫學 2.生物化學 3.幹細胞生物學
電話：03-8561825 分機 15613
電子信箱：cypang@mail.tcu.edu.tw
近五年指導研究生名單：
1.邱勝軍，慈濟大學醫學科學研究所(已畢業)
2.廖家信，慈濟大學醫學科學研究所(已畢業)
3.廖學健，國防醫學院生命科學研究所(已畢業)
4.李典錕，慈濟大學醫學科學研究所
5.陳郁志，慈濟大學醫學科學研究所
6.李佳榮，慈濟大學醫學科學研究所(已畢業)
7.黃麗娟，慈濟大學醫學科學研究所
8.陳冠毓，慈濟大學醫學科學研究所 研究計畫：
|
序號 |
獎助單位 |
計劃編號 |
研究計劃名稱 |
執行期間(起) |
執行期間(迄) |
|
1 |
慈濟醫院 | TCSP-98-02 | 不同來源間質幹細胞治療慢性脊髓損傷成效的評估及臨床運用(1) |
2009.08 |
2010.07 |
|
2 |
慈濟醫院 | TCSP-01-02 | 以6-OHDA誘發類帕金森氏症大白鼠研究G-CSF 對多巴胺神經細胞的神經保護與神經調節功能(1) |
2009.01 |
2009.12 |
|
3 |
慈濟醫院 | TCRD-I9801-03 | 不同組織來源且具醫療應用價值心肌幹細胞的分離純化與定性分析(1) |
2009.02 |
2010.01 |
|
4 |
教育部 | MOE98243A | 98年生物及醫學科技人才培育計畫(馮清榮) |
2009.01 |
2009.12 |
|
5 |
慈濟醫院 | TCRD98-15 | 顆粒性白血球族群刺激因子經由一氧化氮機制改善內皮素-1所誘發大白鼠中腦動脈缺血之紋狀體血流 |
2009.01 |
2009.12 |
|
6 |
慈濟醫院 | TCSP-01-02 | 以6-OHDA誘發類帕金森氏症大白鼠研究G-CSF 對多巴胺神經細胞的神經保護與神經調節功能(2) |
2010.01 |
2010.12 |
|
7 |
教育部 | MOE99243A | 99年生物及醫學科技人才培育計畫(馮清榮) |
2010.01 |
2010.12 |
|
8 |
慈濟醫院 | TCSP-98-02 | 不同來源間質幹細胞治療慢性脊髓損傷成效的評估及臨床運用(2) |
2010.08 |
2011.07 |
|
9 |
慈濟醫院 | TCSP-98-02 | 不同來源間質幹細胞治療慢性脊髓損傷成效的評估及臨床運用(3) |
2011.08 |
2012.07 |
|
10 |
教育部 | MOE100243A | 100年生物及醫學科技人才培育計畫(馮清榮) |
2011.01 |
2011.12 |
|
11 |
慈濟醫院 | TCSP-01-02 | 以6-OHDA誘發類帕金森氏症大白鼠研究G-CSF 對多巴胺神經細胞的神經保護與神經調節功能(3) |
2011.01 |
2011.12 |
|
12 |
慈濟醫院 | TCRD-I9801-03 | 不同組織來源且具醫療應用價值心肌幹細胞的分離純化與定性分析(2) |
2011.01 |
2011.12 |
|
13 |
慈濟基金會 | SC-1-2(102) | 比較自體骨髓單核球細胞和脂肪組織幹細胞以脊髓腔注射方式治療脊髓損傷療效的臨床前試驗(動物模式) |
2012.01 |
2013.12 |
|
14 |
慈濟基金會 | SC-2-1(102) | 尿皮質素做為神經損傷與神經退化疾病治療的臨床前研究 |
2012.01 |
2013.12 |
|
15 |
慈濟醫院 | TCRD-I101-05-02(1/3) | 人類間質幹細胞之臨床級微載體製程開發與應用研究(1/3) |
2012.01 |
2012.12 |
|
16 |
慈濟醫院 | TCRD102-45 | 以腦溢血大鼠探討酒精加劇傷害之現象及機制 |
2013.01 |
2013.12 |
|
17 |
慈濟醫院 | TCRD-I101-05-02(2/3) | 人類間質幹細胞之臨床級微載體製程開發與應用研究(2/3) |
2013.01 |
2014.12 |
|
18 |
慈濟醫院 | TCRD101-30 | 探討尿皮質素保護大白鼠腦溢血之機制與訊息傳遞路徑(2) |
2013.01 |
2013.12 |
|
19 |
慈濟醫院 | TCRD103-19 | 以腦溢血大鼠探討酒精加劇傷害之機制 |
2014.01 |
2014.12 |
|
20 |
慈濟基金會 | SC-2-1(103) | 尿皮質素做為神經損傷與神經退化疾病治療的臨床前研究 |
2014.01 |
2014.12 |
|
21 |
慈濟醫院 | TCRD-I101-05-02(3/3) | 人類間質幹細胞之臨床級微載體製程開發與應用研究(3/3) |
2015.01 |
2015.12 |
|
22 |
慈濟醫院 | TCRD104-29 | 單參酮IIA對人類惡性腦瘤細胞株之生長抑制與機轉探討 |
2015.01 |
2015.12 |
|
23 |
慈濟基金會 | SC-2-1(104) | 尿皮質素做為神經損傷與神經退化疾病治療的臨床前研究 |
2015.01 |
2015.12 |
著作：
- Li CJ, Sun LY, Pang CY. Synergistic Protection of N-Acetylcysteine and Ascorbic Acid 2-Phosphate on Human Mesenchymal Stem cells Against Mitoptosis, Necroptosis and Apoptosis. Sci Reports, in press.
- Liew HK, Kuo JS, Wang JY, Pang CY. Granulocyte-Colony Stimulating Factor Increases Cerebral Blood Flow via a NO Surge Mediated by Akt/eNOS Pathway to Reduce Ischemic Injury. Scientific World J. Article ID 657932, in press.
- Huang HY, Chiu TL, Chang HF, Hsu HR, Pang CY, Liew HK, Wang MJ. Epigenetic Regulation Contributes to Urocortin-Enhanced Midbrain Dopaminergic Neuron Differentiation. Stem Cells. 2015 Jan 13. doi: 10.1002/stem.1949. [Epub ahead of print] PubMed PMID: 25641682.
- Chou CL, Pang CY, Lee TJ, Fang TC. Beneficial effects of calcitriol on hypertension, glucose intolerance, impairment of endothelium-dependent vascular relaxation, and visceral adiposity in fructose-fed hypertensive rats. PLoS One. 2015 Mar 16;10(3):e0119843. doi: 10.1371/journal.pone.0119843. eCollection 2015. PubMed PMID: 25774877.
- Chiu SC, Huang SY, Chang SF, Chen SP, Chen CC, Lin TH, Liu HH, Tsai TH, Lee SS, Pang CY, Hsieh TF. Potential therapeutic roles of tanshinone IIA in human bladder cancer cells. Int J Mol Sci. 2014 Sep 4;15(9):15622-37. doi: 10.3390/ijms150915622. PubMed PMID: 25192287; PubMed Central PMCID: PMC4200770.
- Chiu SC, Huang SY, Chen SP, Su CC, Chiu TL, Pang CY. Tanshinone IIA inhibits human prostate cancer cells growth by induction of endoplasmic reticulum stress in vitro and in vivo. Prostate Cancer Prostatic Dis. 2013 Dec;16(4):315-22. doi: 10.1038/pcan.2013.38. Epub 2013 Sep 17. PubMed PMID: 24042854.
- Pang CY, Chiu SC, Harn HJ, Zhai WJ, Lin SZ, Yang HH.Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells.Food Chem Toxicol,59C:281-288,2013 Jun.(SCI)
- Liao CH, Chen SY, Kuo JS, Pang CY.Reduction of Motor Disorder in 6-OHDA-Induced Severe Parkinsonism Rats by Post Treatment with Granulocyte-Colony Stimulating Factor.Chinese J Physiol,56(3): 147-154.2013.(SCI)
- Yang JR, Liao CH, Pang CY, Huang LL, Chen YL, Shiue YL, Chen LR.Transplantation of porcine embryonic stem cells and their derived neuronal progenitors in a spinal cord injury rat model.Cytotherapy,15(2):201-8,2013 Feb.(SCI)
- Lin HZ, Pang CY, Chen SP, Tsai RK.Vision improvement in a Taiwanese (Han Chinese) family with Leber’s hereditary optic neuropathy.Kaohsiung J Med Sci,28(12):679-82,2012 Dec.(SCI)
- Fang TC, Pang CY, Chiu SC, Ding DC, Tsai RK.Renoprotective effect of human umbilical cord-derived mesenchymal stem cells in immunodeficient mice suffering from acute kidney injury.PLoS One,7(9):e46504,2012.(SCI)
- Chen SP, Wu CC, Huang SY, Kang JC, Chiu SC, Yang KL, Pang CY.β-catenin and K-ras mutations and RASSF1A promoter methylation in Taiwanese colorectal cancer patients.Genet Test Mol Biomarkers,16(11):1277-81,2012 Nov.(SCI)
- Chou CL, Pang CY, Lee TJ, Fang TC.Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats.Hypertens Res,36(2):123-8,2013 Feb.(SCI)
- Yang KL, Lee JT, Pang CY, Lee TY, Chen SP, Liew HK, Chen SY, Chen TY, Lin PY.Human adipose-derived stem cells for the treatment of intracerebral hemorrhage in rats via femoral intravenous injection.Cell Mol Biol Lett,17(3):376-92,2012 Sep.(SCI)
- Chiu SC, Chen SP, Huang SY, Wang MJ, Lin SZ, Harn HJ, Pang CY.Induction of apoptosis coupled to endoplasmic reticulum stress in human prostate cancer cells by n-butylidenephthalide.PLoS One,7(3):e33742,2012.(SCI)
- Chiu SC, Huang SY, Tsai YC, Chen SP, Pang CY, Lien CF, Lin YJ, Yang KT.Poly (ADP-ribose) polymerase plays an important role in intermittent hypoxia-induced cell death in rat cerebellar granule cells.J Biomed Sci,19:29,2012 Mar.(SCI)
- Liew HK, Pang CY, Hsu CW, Wang MJ, Li TY, Peng HF, Kuo JS, Wang JY.Systemic administration of urocortin after intracerebral hemorrhage reduces neurological deficits and neuroinflammation in rats.J Neuroinflammation,09:13,2012 Jan.(SCI)
- Liew HK, Hsu CW, Wang MJ, Kuo JS, Li TY, Peng HF, Wang JY, Pang CY.Therapeutic benefit of urocortin in rats with intracerebral hemorrhage.J Neurosurg,116(1):193-200,2012 Jan.(SCI)
- Chuang JY, Liew HK, Pang CY, Kuo JS.Size-controllable striatal lesion model for evaluation of neuroprotective agents in rats.Tzu Chi Med J,http://dx.doi.org/10.1016/j.tcmj.2013.01.013,2013 March.
- Liew HK, Hsu CW, Kuo JS, Pang CY.Granulocyte-colony stimulating factor reduces striatal dopamine accumulation caused by cerebral ischemia.Tzu Chi Med J,24:181-185,2012 Dec
- Chiu SC, Wang MJ, Yang HH, Chen SP, Huang SY, Chen YL, Lin SZ, Harn HJ, Pang CY. Activation of NAG-1 via JNK signaling revealed an isochaihulactone-triggered cell death in human LNCaP prostate cancer cells. BMC Cancer, 11, p146, 2011.04. (SCI)
- Lin BF, Ou MC, Chung SS, Pang CY, Chen HH. Adolescent toluene exposure produces enduring social and cognitive deficits in mice: An animal model of solvent-induced psychosis. World J Biol Psychiatry, 11, p792, 2010.09. (SCI)
- Yang JR, Liao CH, Pang CY, Huang LL, Lin YT, Chen YL, Shiue YL, Chen LR. Directed differentiation into neural lineages and therapeutic potential of porcine embryonic stem cells in rat Parkinson’s disease model. Cell Reprogram, 12, p447, 2010.08 (SCI)
- Yang KL, Chen MF, Liao CH, Pang CY, Lin PY. A simple and efficient method for generating Nurr1-positive neuronal stem cells from human wisdom teeth (tNSC) and the potential of tNSC for stroke therapy. Cytotherapy, 11, p606, 2009. (SCI)
- Chen SP, Chiu SC, Wu CC, Lin SZ, Kang JC, Chen YL, Lin PC, Pang CY, Harn HJ. The association of methylation in the promoter of APC and MGMT and the prognosis of Taiwanese CRC patients. Genetic Testing, 13, p67, 2009.02 (SCI)
- Chen SP, Wu CC, Lin SZ, Kang JC, Su CC, Chen YL, Lin PC, Chiu SC, Pang CY, Harn HJ. Prognostic significance of interaction between somatic APC mutations and 5-fluorouracil adjuvant chemotherapy in Taiwanese colorectal cancer subjects. Am J Clin Oncol. 32, p122, 2009 (SCI)