張孟雅 副教授

mchang
最高學歷: 英國愛丁堡大學細胞生物及分子生物博士
現任經歷: 慈濟大學醫學科學研究所副教授
研究領域: 1. 基因治療, 2. 奈米醫學
電話:03-8561825 分機 5617
電子信箱: mchang@mail.tcu.edu.tw

近五年指導研究生名單:

1.江家瑋,慈濟大學分遺所碩士班(已畢業)

2.周育誠,慈濟大學醫學科學研究所

研究計畫:

序號

獎助單位

計劃編號

研究計劃名稱

執行期間(起)

執行期間(迄)

1

國科會 NSC99-2320-B-320-002- 利用腺病毒載體攜帶前胸線素基因併用介白素12

2010.3

2011.7

2

慈濟醫院 TCRD-I9902-01 【癌症幹細胞與微環境在癌症生成、侵犯、轉移之研究】子計畫一【子宮頸癌症鄰近基質組織之表徵遺傳研究」

2011.2

2012.1

3

慈濟醫院 TCRD102-36 卵巢微環境對輸卵管繖部上皮細胞至漿液性卵巢癌發展上之影響

2013.1

2013.12

著作:

1.Shiau AL, Teo ML, Chen SY, Wang CR, Hsieh JL, Chang MY, Chang CJ, Chao J, Chao L, Wu CL, Lee CH.*Inhibition of experimental lung metastasis by systemic lentiviral delivery of kallistatin. BMC Cancer,10:245-253, 2010 (SCI)

2.Hsieh YJ, Yang MY, Leu YL, Chen C, Wan CF, Chang MY, Chang CJ.*Kalanchoe tubiflora extract inhibits cell proliferation by affecting the mitotic apparatus. BMC Complement Altern Med. ,12:149-158, 2012 (SCI)

3.Huang YJ, Shiau AL, Chen SY, Chen YL, Wang CR, Tsai CY, Chang MY, Li YT, Leu CH, Wu CL.*Multivalent structure of galectin-1-nanogold complex serves as potential therapeutics for rheumatoid arthritis by enhancing receptor clustering. Eur Cell Mater. ,23:170-181, 2012 (SCI)

4.Hsieh, JL; Lu, CS; Huang, CL; Shieh, GS; Su, BH; Su, YC; Lee, CH; Chang, MY; Wu, CL; Shiau, AL. Acquisition of an enhanced aggressive phenotype in human lung cancer cells selected by suboptimal doses of cisplatin following cell deattachment and reattachment Cancer Lett. ,321:36-44, 2012 (SCI)

5.Chang, MY; Cheng, YJ; Chang, WW; Wang, WK; Liu, CF; Lin, ST; Lee, CH*. Resveratrol Enhances Chemosensitivity in Mouse Melanoma Model Through Connexin 43 Upregulation Environmental Toxicology DOI: 10.1002/tox.21952 , 2014 (SCI)

6.Chang, MY; Yang, YS;Tsai, ML; Lee, CH; Chang, CJ; Shiau, AL*; Wu, CL*. Adenovirus-mediated prothymosin alpha gene transfer inhibits the development of atherosclerosis in ApoE-deficient mice International Journal of Biological Sciences(Inpress), 2014 (SCI)

7.Chao, TH, Chang, MY , Su, SJ, Su, SH. Inducible nitric oxide synthase mediates MG132 lethality in leukemic cells through mitochondrial depolarization. Free Radical Biology and Medicine, 74:175–187,2014 (SCI)

8.Chou, YC, Chang, MY, Wang, MJ, Harnod, T, Hung, CH, Lee, HT, Shen, CC, Chung, JGPEITC induces apoptosis of Human Brain Glioblastoma GBM8401 Cells through the extrinsic- and intrinsic -signaling pathways. Neurochem Int,81:32-40,2015(SCI)

9.Chou, YC, Chang, MY, Wang, MJ, Yu, FS, Liu HC, Harnod, T, Hung, CH, Lee, HT, Chung, JG.PEITC inhibits human brain glioblastoma GBM 8401 cell migration and invasion through the inhibition of uPA, Rock1, and Ras with inhibition of MMP-2, -7 and -9 gene expression. Oncology reports,34(5):2489-96,2015(SCI)

10.Leu CH, Yang ML, Chung NH, Huang YJ, Su YC, Chen YC, Lin CC, Shieh GS, Chang MY, Wang SWi, Chang Y, Chao J, Chao L, Wu CL, Shiau AL Kallistatin Ameliorates Influenza Virus Pathogenesis by Inhibition of Kallikrein-Related Peptidase 1-Mediated Cleavage of Viral Hemagglutinin. Antimicrobial Agents and Chemotherapy,59(9):5619-30,2015(SCI)

11.Hsieh YJn, Huang HS, Leu YL, Peng KC, Chang CJ, Chang MYAnticancer activity of Kalanchoe tubiflora extract against human lung cancer cells in vitro and in vivo. Environmental Toxicology,doi: 10.1002/tox.22170,2015(SCI)

12.Huang HS, Chu SC, Hsu CF, Chen PC, Ding DC, Chang MY, Chu TYMutagenic, surviving and tumorigenic effects of follicular fluid in the context of p53 loss: initiation of fimbria carcinogenesis.Carcinogenesis,36(11):1419-28,2015(SCI)

13.Lu CS, Hsieh JL, Lin CY, Tsai HW, Su BH, Shieh GS, Su YC, Lee CH, Chang MY, Wu CL, Shiau AL.Potent antitumor activity of Oct4 and hypoxia dual-regulated oncolytic adenovirus against bladder cancer. Gene Ther,22(4):305-15,2015(SCI)

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